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Case Report

Diagnostic and Treatment Strategies for Chronic Uterine Inversion: A Rare Case Report

El Mhabrech H

Chronic non-puerperal uterine inversion is an uncommon gynecological condition that is frequently misdiagnosed as a prolapsed submucosal leiomyoma, often resulting in delayed diagnosis and management. We report the case of a 41-year-old woman presenting with a six-month history of persistent metrorrhagia and severe anemia, who was subsequently diagnosed with a grade 3 uterine inversion caused by a large, prolapsed endometrial mass. Management involved initial exploratory laparoscopy, followed by conversion to laparotomy, culminating in a total hysterectomy with bilateral salpingo-oophorectomy. Histopathological analysis confirmed high-grade endometrial stromal sarcoma.

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Review Article

Spontaneous Remission in Follicular Lymphoma with Localized Relapse

Akram Karama

Follicular lymphoma (FL) is a slow-growing malignancy often managed with a “watch and wait” policy in asymptomatic, advanced-stage cases. Spontaneous remission, a rare but documented phenomenon, further validates this conservative approach. This case report details the clinical course of a 47-year-old male with an initially asymptomatic Stage 3 classical FL (Grade 1-2). After a two-year period of watchful waiting, the patient experienced a spontaneous remission that lasted for over a year. The disease later relapsed in a localized form, presenting as a Stage 1 cervical recurrence. This was successfully managed with active therapy using a monoclonal antibody (Rituximab) and localized radiotherapy.

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Research Article

Laboratory Investigation of Neuroplasticity Markers in Chronic Pain: Correlating Pain Severity with Functional

Syed Basit Ali Shah

Chronic pain, persisting beyond the expected period of healing, leads to significant neuroplastic changes in the brain’s structure and function. This study explores the relationship between chronic pain severity and brain alterations, focusing on gray matter atrophy and altered functional connectivity within pain-related regions. Using structural MRI and functional MRI (fMRI), we evaluated 80 patients with chronic pain and 40 control participants. Significant gray matter atrophy was observed in the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and thalamus in chronic pain patients, with atrophy severity correlating with higher pain intensity scores. Functional connectivity analysis revealed increased connectivity between the insula and ACC, associated with heightened emotional pain processing, and decreased connectivity between the PFC and brainstem, indicating impaired descending pain modulation.

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Short Commentary

Long-Lasting Response with Anti-PD-1 Antibody Following Progression on Anti-PD-L 1 Antibody in Advanced Non-Small Cell Lung Cancer (NSCLC): A Case Report and Review of the Literature

Lika Chkhaidze, MD *; Anna Geguchadze, MD; Mariam Vakhtangishvili, MD ; Ivane Kiladze, MD, PhD

Lung cancer is the leading cause of cancer incidence and mortality worldwide [1]. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases, with around 1 million new diagnoses of advanced NSCLC (aNSCLC) each year worldwide [2,3]. The prognosis for aNSCLC remains poor, with a 1-year survival rate of only 29% following cytotoxic chemotherapy [4].

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Short Commentary

Breast Cancer Risk in MSH6 And MSH2 Role in Lynch Syndrome Female Patients: A Single Institution Retrospective Analysis

Salvatora Tindara Miano*; Roberto Petrioli

Lynch syndrome (LS) is a germ pathogenic mutations involving DNA Mismatch Repair (MMR) genes: LS is linked with the development of MMR-deficient (MMRd) cancers and is associated with an increased risk of several malignancies including gastrointestinal, genitourinary, gynecologic, skin, and brain cancers.

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